Since the team was established in 2011, we have published more than 120 original peer-reviewed research papers and over 30 invited reviews and editorials on the topic of lifestyle management, exercise and physical activity in kidney disease. Our key publications are listed below. For a full list of our publications on PubMed please click here.
Guideline Documents
Baker LA, March DS, Wilkinson TJ, Billany RE, Bishop NC, Castle EM, Chilcot J, Davies MD, Graham-Brown MP, Greenwood SA, Junglee NA. Clinical practice guideline exercise and lifestyle in chronic kidney disease. BMC nephrology. 2022;23(1):1-36. doi:10.1186/s12882-021-02618-1
Recent Invited Reviews and Editorials
Lightfoot CJ, Wilkinson TJ, Smith AC. Non-pharmacological management of chronic kidney disease. Medicine. 2023. doi:10.1016/j.mpmed.2022.12.004
Lightfoot CJ, Nair D, Bennett PN, Smith AC, Griffin AD, Warren M, Wilkinson TJ. Patient activation: the cornerstone of effective self-management in chronic kidney disease?. Kidney and Dialysis. 2022;2(1):91-105. doi:10.3390/kidneydial2010012
Lightfoot CJ, Howell M, Smith AC. How to assess quality of life in persons with chronic kidney disease. Current Opinion in Nephrology and Hypertension. 2021;30(6):547-54. doi:10.1097/MNH.0000000000000740
Wilkinson TJ, Smith AC. Physical activity and living well with kidney disease. Nature Reviews Nephrology. 2021;17(3):145-6. doi:10.1038/s41581-021-00398-3
Key Original Research Articles
Lightfoot, C.J, Wilkinson, T.J, Vadaszy, N, Graham-Brown, M.P.M, Davies, M.J, Yates, T. Smith, AC. Improving self-management behaviour through a digital lifestyle intervention: an internal pilot study. Journal of Renal Care. 2024;1–14. https://doi.org/10.1111/jorc.12488
Lightfoot, C.J, Wilkinson, T.J, Patel, N.A. et al. Patient activation and psychological coping strategies to manage challenging circumstances during the COVID-19 pandemic in people with kidney disease. Journal of Nephrology. 2024. https://doi.org/10.1007/s40620-023-01851-1
Lightfoot, CJ, Wilkinson, TJ, Patel, NA, Jones, CR, , et al. Patient activation and psychological coping strategies to manage challenging circumstances during the COVID-19 pandemic in people with kidney disease. Journal of Nephrology. 2024;1-12. https://doi.org/10.1007/s40620-023-01851-1
Lightfoot CJ, Wilkinson TJ, Hadjiconstantinou M, Graham-Brown M, Barratt J, Brough C, et al. The Codevelopment of “My Kidneys & Me”: A Digital Self-management Program for People With Chronic Kidney Disease. Journal of Medical Internet Research. 2022;24(11):e39657-e. doi:10.2196/39657
Lightfoot CJ, Wilkinson TJ, Yates T, Davies MJ, Smith AC. 'Self-Management Intervention through Lifestyle Education for Kidney health' (the SMILE-K study): protocol for a single-blind longitudinal randomised controlled trial with nested pilot study. BMJ Open. 2022;12:064916. doi:10.1136/ bmjopen-2022-064916
Wilkinson TJ, Palmer J, Gore EF, Smith AC. The validity of the ‘General Practice Physical Activity Questionnaire’ against accelerometery in patients with chronic kidney disease. Physiotherapy Theory and Practice. 2022;38(10):1528-37. doi/10.1080/09593985.2020.185568
Wilkinson TJ, Miksza J, Zaccardi F, Lawson C, Nixon AC, Young HML, et al. Associations between frailty trajectories and cardiovascular, renal, and mortality outcomes in chronic kidney disease. Journal of Cachexia, Sarcopenia and Muscle. 2022;13(5):2426-35. doi:10.1002/jcsm.13047
Hutchinson GM, Cooper AM, Billany RE, Nixon DGD, Bishop NC, Smith AC. Exercise in kidney transplant recipients: effects on immune and inflammatory cells Effect of high intensity interval training and moderate intensity continuous training on lymphoid, myeloid and inflammatory cells in kidney transplant recipients. EIR. 2022;28:100-15.) doi:10.1186/s40814-022-01067-3
Baker LA, O'Sullivan TF, Robinson KA, Graham-Brown MPM, Major RW, Ashford RU, et al. Primary skeletal muscle cells from chronic kidney disease patients retain hallmarks of cachexia in vitro. Journal of Cachexia, Sarcopenia and Muscle. 2022;13(2):1238-49. doi:10.1002/jcsm.12802
Watson EL, Baker LA, Wilkinson TJ, Gould DW, Xenophontos S, Graham-Brown M, et al. Inflammation and physical dysfunction: responses to moderate intensity exercise in chronic kidney disease. Nephrology Dialysis Transplantation. 2022;37(5):860-8. doi:10.1093/ndt/gfab333
Lightfoot CJ, Wilkinson TJ, Memory KE, Palmer J, Smith AC. Reliability and validity of the patient activation measure in kidney disease: Results of rasch analysis. Clinical Journal of the American Society of Nephrology. 2021;16(6):880-8. doi:10.2215/CJN.19611220
Wilkinson TJ, Miksza J, Yates T, Lightfoot CJ, Baker LA, Watson EL, et al. Association of sarcopenia with mortality and end-stage renal disease in those with chronic kidney disease: a UK Biobank study. Journal of Cachexia, Sarcopenia and Muscle. 2021;12(3):586-98. doi:10.1002/jcsm.12705
Wilkinson TJ, Clarke AL, Nixon DGD, Hull KL, Song Y, Burton JO, et al. Prevalence and correlates of physical activity across kidney disease stages: an observational multicentre study. Nephrology Dialysis Transplantation. 2021;36(4):641-9. doi:10.1093/ndt/gfz235
Watson EL, Baker LA, Wilkinson TJ, Gould DW, Graham-Brown MPM, Major RW, et al. Reductions in skeletal muscle mitochondrial mass are not restored following exercise training in patients with chronic kidney disease. FASEB Journal. 2020;34(1):1755-67. doi:10.1096/fj.201901936RR
Gould DW, Watson EL, Wilkinson TJ, Wormleighton J, Xenophontos S, Viana JL, et al. Ultrasound assessment of muscle mass in response to exercise training in chronic kidney disease: a comparison with MRI. Journal of Cachexia, Sarcopenia and Muscle. 2019;10(4):748-55. doi:10.1002/jcsm.12429
Clarke AL, Zaccardi F, Gould DW, Hull KL, Smith AC, Burton JO, et al. Association of self-reported physical function with survival in patients with chronic kidney disease. Clinical Kidney Journal. 2019;12(1):122-8. doi:10.1093/ckj/sfy080
Brown SA, Tyrer F, Clarke AL, Lloyd-Davies LH, Niyi-Odumosu FA, Nah RGQ, et al. Kidney symptom questionnaire: Development, content validation and relationship with quality of life. Journal of renal care. 2018;44(3):162-73. doi:10.1111/jorc.12247
Emma Watson XL, Gould DW, Wilkinson TJ, Xenophontos S, Clarke AL, Perez Vogt B, et al. Twelve-week combined resistance and aerobic training confers greater benefits than aerobic training alone in nondialysis CKD. Am J Physiol Renal Physiol. 2018;314:1188-96. doi:10.1152/ajprenal.00012.2018
Watson EL, Viana JL, Wimbury D, Martin N, Greening NJ, Barratt J, et al. The effect of resistance exercise on inflammatory and myogenic markers in patients with chronic kidney disease. Frontiers in Physiology. 2017;8(JUL):541-. doi:10.3389/fphys.2017.00541
Viana JL, Kosmadakis GC, Watson EL, Bevington A, Feehally J, Bishop NC, et al. Evidence for anti-inflammatory effects of exercise in CKD. Journal of the American Society of Nephrology. 2014;25(9):2121-30. doi:10.1681/ASN.2013070702
Watson EL, Kosmadakis GC, Smith AC, Viana JL, Brown JR, Molyneux K, et al. Combined walking exercise and alkali therapy in patients with CKD4-5 regulates intramuscular free amino acid pools and ubiquitin E3 ligase expression. European Journal of Applied Physiology. 2013;113(8):2111-24. doi:10.1007/s00421-013-2628-5
Kosmadakis GC, John SG, Clapp EL, Viana JL, Smith AC, Bishop NC, et al. Benefits of regular walking exercise in advanced pre-dialysis chronic kidney disease. Nephrology Dialysis Transplantation. 2012;27(3):997-1004. doi:10.1093/ndt/gfr364
